Poor man's CSS Framework
If you have simple site structure, for example classic: header, left panel, content panel and footer, then it may be an option to skip full scale css framework. JQuery introduced "position" utility. Here is how I stitched my content panel to the left panel:
$('#pages').position({
of: $('#main-menu'),
my: "left top",
at: "right top"
})
No stupid tricks with css margins!
Taking into account that css3 layout won't be ready any soon and taking into account not the best architecture of css overall, jQuery can become layout engine of the choice in the future.